Sulfur mediated propargylic C–H alkylation of alkynes

Abstract

A transition-metal-free, sulfur mediated propargylic C–H alkylation reaction was realized through a one-pot procedure. The reaction design involves an initial addition between alkynes and triflic anhydride activated sulfoxides, and a subsequent [2,3]-sigmatropic rearrangement of the allenyl sulfur ylides generated under basic conditions to give propargylic C–H alkylation products.