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Sulfur mediated propargylic C–H alkylation of alkynes

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Abstract

A transition-metal-free, sulfur mediated propargylic C–H alkylation reaction was realized through a one-pot procedure. The reaction design involves an initial addition between alkynes and triflic anhydride activated sulfoxides, and a subsequent [2,3]-sigmatropic rearrangement of the allenyl sulfur ylides generated under basic conditions to give propargylic C–H alkylation products.

Graphical abstract: Sulfur mediated propargylic C–H alkylation of alkynes

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Publication details

The article was received on 23 Apr 2018, accepted on 04 Jun 2018 and first published on 05 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QO00410B
Citation: Org. Chem. Front., 2018, Advance Article
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    Sulfur mediated propargylic C–H alkylation of alkynes

    G. Hu, J. Xu and P. Li, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00410B

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