A facile method for the synthesis of trifluoromethylthio-/chloro-homoallylic alcohols from methylenecyclopropanes

Abstract

A facile method for the synthesis of trifluoromethylthio-homoallylic alcohols from methylenecyclopropanes (MCPs) has been achieved with the application of (PhSO₂)₂NSCF₃ in N,N-dimethyl formamide (DMF). It has been proved that DMF plays a role both as a solvent and a reagent. Meanwhile, we find that (PhSO₂)₂NCl is also an active reagent to afford chloro-homoallylic alcohols in the same way as (PhSO₂)₂NSCF₃, and it is very convenient to convert the product to the corresponding amido- or bromo-substituted compounds.