Jump to main content
Jump to site search

Issue 15, 2018
Previous Article Next Article

A Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles with indole-derived ketimines: rapid access to hexacyclic spiroindolines

Author affiliations

Abstract

We report a Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles and indole-derived ketimines to rapidly afford hexacyclic spiroindolines featuring three stereocenters including two quaternary stereocenters in moderate to excellent yields (30–89%) with complete diastereoselectivity. This reaction is highly efficient because two C–C and one C–N bonds as well as two new rings are created under mild reaction conditions in a single step.

Graphical abstract: A Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles with indole-derived ketimines: rapid access to hexacyclic spiroindolines

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Apr 2018, accepted on 08 Jun 2018 and first published on 08 Jun 2018


Article type: Research Article
DOI: 10.1039/C8QO00382C
Citation: Org. Chem. Front., 2018,5, 2303-2307
  •   Request permissions

    A Zn(OTf)2 catalyzed Ugi-type reaction of 3-(2-isocyanoethyl)indoles with indole-derived ketimines: rapid access to hexacyclic spiroindolines

    Y. Liu, X. Mao, X. Lin and G. Chen, Org. Chem. Front., 2018, 5, 2303
    DOI: 10.1039/C8QO00382C

Search articles by author

Spotlight

Advertisements