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Issue 10, 2018
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Metal-free aerobic oxidative direct C–H amination of electron-deficient alkenes via photoredox catalysis

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Abstract

The first example of photocatalytic dehydrogenative cross-coupling of electron-poor alkenes with azoles has been reported. This method provides a novel approach for N-vinylazole synthesis, which enables coupling of a broad scope of azoles and electron-deficient alkenes in an atom- and redox-economical manner. The present work opens up a new avenue to rapidly access mild C(sp2)–H amination by using rose bengal as an organophotocatalyst. The mild conditions, easy availability of alkenes and operational simplicity make the reaction useful in the synthesis of diverse substituted N-vinylazoles.

Graphical abstract: Metal-free aerobic oxidative direct C–H amination of electron-deficient alkenes via photoredox catalysis

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Publication details

The article was received on 07 Mar 2018, accepted on 29 Mar 2018 and first published on 02 Apr 2018


Article type: Research Article
DOI: 10.1039/C8QO00161H
Citation: Org. Chem. Front., 2018,5, 1684-1688
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    Metal-free aerobic oxidative direct C–H amination of electron-deficient alkenes via photoredox catalysis

    J. Xin, Y. He and Z. Guan, Org. Chem. Front., 2018, 5, 1684
    DOI: 10.1039/C8QO00161H

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