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Issue 8, 2018
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Copper-catalyzed diarylation of Se with aryl iodides and heterocycles

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Abstract

The site-selective copper-catalyzed three-component coupling reaction of electron-deficient heterocycles, Se powder and aryl iodides is disclosed. The established methodology provides an efficient and practical pathway to access 2-arylselenated heterocycles via copper-catalyzed double C–Se bond formation. This transformation features the use of elemental Se as the selenating reagent, a cost-effective catalytic system, and the late-stage selenation of bioactive compounds.

Graphical abstract: Copper-catalyzed diarylation of Se with aryl iodides and heterocycles

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Publication details

The article was received on 20 Jan 2018, accepted on 26 Feb 2018 and first published on 08 Mar 2018


Article type: Research Article
DOI: 10.1039/C8QO00066B
Citation: Org. Chem. Front., 2018,5, 1352-1355
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    Copper-catalyzed diarylation of Se with aryl iodides and heterocycles

    D. Hu, M. Liu, H. Wu, W. Gao and G. Wu, Org. Chem. Front., 2018, 5, 1352
    DOI: 10.1039/C8QO00066B

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