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Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

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Abstract

Efficient palladium-catalyzed C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles was developed by using diethyl azodicarboxylate as the esterification reagent. A wide variety of aryl esters containing 1,2,3-triazoles were obtained in moderate to good yields. In addition, density functional theory calculations were used to enhance the mechanistic studies.

Graphical abstract: Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

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Publication details

The article was received on 18 Oct 2017, accepted on 13 Nov 2017 and first published on 15 Nov 2017


Article type: Research Article
DOI: 10.1039/C7QO00945C
Citation: Org. Chem. Front., 2018, Advance Article
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    Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant

    R. Sang, Y. Zheng, H. Zhang, X. Wu, Q. Wang, L. Hai and Y. Wu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C7QO00945C

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