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Issue 28, 2018
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Synthesis of novel guanidine-based ABA triblock copolymers and their antimicrobial honeycomb films

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Abstract

Novel amphiphilic poly(methacryl guanidine hydrochloride)-block-polystyrene-block-poly(methacryl guanidine hydrochloride) (PMAGH-b-PS-b-PMAGH) ABA triblock copolymers with a controlled molecular weight and composition were synthesized via sequential reversible addition/fragmentation chain transfer (RAFT) polymerization of methacryl guanidine hydrochloride (MAGH) and styrene, using S,S′-bis (α,α′-dimethyl-α′′-acetic acid) trithiocarbonate (BDATC) as the initial chain transfer agent. Highly ordered honeycomb films of PMAGH-b-PS-b-PMAGH were fabricated via a facile and versatile static breath-figure process. PMAGHs and the honeycomb films of PMAGH-b-PS-b-PMAGH showed high antimicrobial activity against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis). The minimum MIC values of PMAGHs are 113 μg mL−1 for E.coli and 450 μg mL−1 for B. subtilis. PMAGH-b-PS-b-PMAGH honeycomb films inhibited 61% of E. coli and 92% of B. subtilis.

Graphical abstract: Synthesis of novel guanidine-based ABA triblock copolymers and their antimicrobial honeycomb films

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Publication details

The article was received on 16 May 2018, accepted on 26 Jun 2018 and first published on 26 Jun 2018


Article type: Paper
DOI: 10.1039/C8PY00732B
Citation: Polym. Chem., 2018,9, 3922-3930
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    Synthesis of novel guanidine-based ABA triblock copolymers and their antimicrobial honeycomb films

    H. Zhang, Y. Liu, T. Luo, Q. Zhao, K. Cui, J. Huang, T. Jiang and Z. Ma, Polym. Chem., 2018, 9, 3922
    DOI: 10.1039/C8PY00732B

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