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Combination of PDT photosensitizers with NO photodononors

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Abstract

Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic effects arising from multiple therapeutic species acting on different mechanistic pathways. The coupling of PDT with photocontrolled release of nitric oxide (NO) through the appropriate assembly of PDT photosensitizers (PSs) and NO photodonors (NOPDs) may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli. In this contribution, we present an overview of the most recent advances in this field, illustrating several strategies to assemble PSs and NOPDs allowing them to operate independently without reciprocal interferences and describing the potential applications with particular emphasis on their impact in anticancer and antibacterial research.

Graphical abstract: Combination of PDT photosensitizers with NO photodononors

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Publication details

The article was received on 28 Jun 2018, accepted on 07 Aug 2018 and first published on 13 Aug 2018


Article type: Perspective
DOI: 10.1039/C8PP00272J
Citation: Photochem. Photobiol. Sci., 2018, Advance Article
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    Combination of PDT photosensitizers with NO photodononors

    A. Fraix and S. Sortino, Photochem. Photobiol. Sci., 2018, Advance Article , DOI: 10.1039/C8PP00272J

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