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Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors

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Abstract

Photothermal therapy (PTT) is providing new opportunities for killing cancer cells. In this work, we introduce a new nanomedicine based on spherical MoS2 nanoparticles for PTT treatment of tumors, prepared using “green” bottom-up technology. To increase water solubility and avoid rapid clearance by the reticuloendothelial system, polyethylene glycol (PEG) was used to coat them. These MoS2-PEG nanospheres with an appropriate size (∼100 nm) exhibit high photothermal conversion efficiency (26.7%). In vitro cellular studies revealed that the MoS2-PEG nanospheres showed negligible cytotoxicity. Additionally, through combining the MoS2-PEG nanosphere samples with NIR irradiation at 808 nm, excellent in vitro tumor cell killing efficacy was achieved. In the 4T1 tumor model, the MoS2-PEG nanospheres exhibited good antitumor efficiency in vivo, displaying complete tumor inhibition over 16 days after treatment. Therefore, MoS2-PEG nanospheres played an important role in tumor destruction, and this concept for developing spherical MoS2-based nanomedicines can serve as a platform technology for the next generation of in vivo PTT agents.

Graphical abstract: Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors

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Publication details

The article was received on 09 May 2018, accepted on 08 Aug 2018 and first published on 16 Aug 2018


Article type: Paper
DOI: 10.1039/C8PP00198G
Citation: Photochem. Photobiol. Sci., 2018, Advance Article
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    Bottom-up synthesis of MoS2 nanospheres for photothermal treatment of tumors

    S. Gao, H. Zhou, S. Cui and H. Shen, Photochem. Photobiol. Sci., 2018, Advance Article , DOI: 10.1039/C8PP00198G

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