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Terpyridine derivative as “turn-on” fluorescent chemosensor for the selective and sensitive detection of Zn2+ ions in solution as well as in live cells

Abstract

A terpyridine based compound L1 was designed and synthesized as “off–on” chemosensor for Zn2+. Chemosensor L1 showed excellent selectivity and sensitivity toward Zn2+ by exhibiting a large fluorescence enhancement (~ 51-fold) at 370 nm whereas other competitive metal ions did not show any noticeable change in the emission spectra of chemosensor L1. The chemosensor (L1) was shown to detect Zn2+ ion down to 9.76 µM at pH 7.4. However, chemosensor L1 binds Zn2+ in a 1:2 ratio (receptor : metal) with an association constant 1.85 × 104 (R2 = 0.993) and this 1:2 stoichiometric fashion is established on the basis of Job’s plot and mass spectroscopy. DFT/TDDFT calculations were carried out to understand the binding nature, coordination feature and electronic properties of L1 and L1-2Zn2+ complex. In addition, this “turn-on” fluorescent probe was effectively used to image intracellular Zn2+ ions in cultured MDA-MB-468 cells.

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Publication details

The article was accepted on 06 Jun 2018 and first published on 06 Jun 2018


Article type: Paper
DOI: 10.1039/C8PP00186C
Citation: Photochem. Photobiol. Sci., 2018, Accepted Manuscript
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    Terpyridine derivative as “turn-on” fluorescent chemosensor for the selective and sensitive detection of Zn2+ ions in solution as well as in live cells

    T. Mandal, A. Hossain , A. Dhara, A. Al Masum, S. konar, S. K. Manna, S. K. Seth, S. Pathak and S. Mukhopadhyay, Photochem. Photobiol. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8PP00186C

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