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Using X-ray in photodynamic therapy: an overview

Abstract

Photodynamic therapy is a therapeutic option to treat cancer and others diseases. PDT is used everyday in dermatology and recent developments in the treatment of glioblastoma, mesothelioma or prostate prove the efficacy of this modality. In order to improve the efficacy of PDT, different strategies are under development such as the use of targeted PS or nanoparticles to improve the selectivity, the design of light devices to better monitor the light dose. Due to the low penetration of light into the tissue, another way to improve the efficacy of PDT to treat deep tumor is the use of upconversion NPs or bi-photon absorption compounds. With these compounds, it is then possible to excite into the red part of the spectrum. A relatively new approach that we will call PDTX is the use of X-ray instead of UV-visible light that can deeply penetrate into the tissue. The principle of this technique will be described and a state of art of the literature concerning this modality will be done. First of all, we will focus onto the different photosensitizers that have been use in combination with X-ray irradiation. To improve the efficacy, nanoparticles have been designed and allow the conversion of high-energy ionizing radiation into UV-visible light potential candidates for PDTX approach. They will be related at the end of this review.

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Publication details

The article was received on 16 Mar 2018, accepted on 04 Jun 2018 and first published on 13 Jun 2018


Article type: Perspective
DOI: 10.1039/C8PP00112J
Citation: Photochem. Photobiol. Sci., 2018, Accepted Manuscript
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    Using X-ray in photodynamic therapy: an overview

    L. Larue, A. Ben Mihoub, Z. Youssef, L. Colombeau, S. Acherar, J. André, P. Arnoux, F. Baros, M. Vermandel and C. Frochot, Photochem. Photobiol. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8PP00112J

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