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Mechanisms of and Variables affecting UVR Photoadaptation in Human Skin

Abstract

Humans have been exposed to UV radiation from the sun since the beginning of time and, due to evolutionary adaptations, most individuals have the capacity to acclimate to this exposure, to some degree. We know that UV radiation produces several deleterious effects in human skin and that light- skinned individuals are at greatest risk for both acute and long-term negative effects. These effects include DNA damage, sunburn, immune suppression and skin cancer. The benefits of photoadaptation, which leads to a decreased response after acclimatization, are that humans can work and play in the sun without fear of painful sunburn. However, the effects of photoadaptation on DNA damage and development of skin cancer are quite complex and less well-understood. In this article, we have reviewed the current state of knowledge on the subject of UV photoadaptation in human skin. However, more studies are needed to explore the use of UV photoadaptation to protect against critical endpoints, such as skin cancer.

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Publication details

The article was received on 21 Nov 2017, accepted on 04 May 2018 and first published on 31 May 2018


Article type: Paper
DOI: 10.1039/C7PP00430C
Citation: Photochem. Photobiol. Sci., 2018, Accepted Manuscript
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    Mechanisms of and Variables affecting UVR Photoadaptation in Human Skin

    M. Garmyn, A. Young and S. Miller, Photochem. Photobiol. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7PP00430C

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