Issue 41, 2018

Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

Abstract

Iodothiocyanation of alkynes with ammonium thiocyanate (NH4SCN) and molecular iodine (I2) has been demonstrated in aqueous ethanol, which enables efficient synthesis of a series of functional β-iodo vinylthiocyanates in good to excellent yields under mild reaction conditions without the need for any protection.

Graphical abstract: Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

Supplementary files

Article information

Article type
Communication
Submitted
08 Sep 2018
Accepted
26 Sep 2018
First published
27 Sep 2018

Org. Biomol. Chem., 2018,16, 7557-7560

Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol

X. Zeng and L. Chen, Org. Biomol. Chem., 2018, 16, 7557 DOI: 10.1039/C8OB02216J

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