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Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

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Abstract

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. HMOs prevent infection by serving as decoy receptors that competitively bind pathogens thus preventing pathogen attachment to host epithelial cell receptors. In a second mechanistic pathway, we recently demonstrated that heterogenous HMO extracts exert antimicrobial action against Group B Streptococcus by increasing cellular permeability. As human milk contains ca. 200 unique glycans however, our understanding of which pharmacophores are most important to HMO antimicrobial activity remains immature. In the present study, we describe the first evaluation of the antimicrobial and antibiofilm activities of five structurally defined, ubiquitous sialylated HMOs against Group B Streptococcus.

Graphical abstract: Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

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Publication details

The article was received on 24 Aug 2018, accepted on 13 Sep 2018 and first published on 13 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB02080A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

    K. M. Craft, H. C. Thomas and S. D. Townsend, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02080A

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