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Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

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Abstract

The first α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved under mild reaction conditions. Several α,β,γ,δ-unsaturated aldehydes and diarylcarbinols are successfully tested for the synthesis of MBH-type α-alkylated products with an excellent regioselectivity. Simple pyrrolidine is efficiently used as a catalyst to achieve a perfect E/Z selectivity of the α-alkylated products.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

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Publication details

The article was received on 22 Aug 2018, accepted on 05 Sep 2018 and first published on 05 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02059K
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

    V. M. D. Padmaja, S. Jangra and C. Appayee, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02059K

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