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Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

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Abstract

A novel, convenient and efficient protocol for the construction of various 2-aminophenyl benzothiazoles by domino intra- and intermolecular C–N cross-coupling reactions of arylisothioureas with aryl iodides using an inexpensive, air stable and readily available copper catalyst is described. The arylisothioureas were obtained from thiourea via copper promoted desulfurization followed by nucleophilic substitution. In addition, the reactivity of arylhalides and the reaction mechanism have also been studied. The protocol features operational simplicity and a broad substrate scope.

Graphical abstract: Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

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Publication details

The article was received on 17 Aug 2018, accepted on 06 Sep 2018 and first published on 06 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB02018C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper-catalyzed synthesis of 2-aminophenyl benzothiazoles: a novel approach

    S. N. M. Boddapati, C. M. Kurmarayuni, B. R. Mutchu, R. Tamminana and H. B. Bollikolla, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02018C

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