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Issue 35, 2018
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Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis

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Abstract

Mild and direct intramolecular oxidative aryltrifluoromethylations of activated alkenes have been established through visible light photocatalysis, affording a range of CF3-containing oxindoles or isoquinolinediones in the presence of an organic fluorophore-type photocatalyst 4CzIPN, oxygen and visible light irradiation under strong oxidant and transition metal free conditions. A variety of frequently encountered functional groups are well tolerated in this transformation.

Graphical abstract: Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis

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Publication details

The article was received on 07 Aug 2018, accepted on 21 Aug 2018 and first published on 22 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01922C
Citation: Org. Biomol. Chem., 2018,16, 6564-6568
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    Synthesis of oxindoles through trifluoromethylation of N-aryl acrylamides by photoredox catalysis

    M. Lu, Z. Liu, J. Zhang, Y. Tian, H. Qin, M. Huang, S. Hu and S. Cai, Org. Biomol. Chem., 2018, 16, 6564
    DOI: 10.1039/C8OB01922C

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