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A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells

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Abstract

A rapid cell-permeating probe NJUXJ-1 was introduced for sensitive and selective detection of sulfite in living cells. It generated a turn-on response to sulfite with high sensitivity (detection limit 13.0 nM) and selectivity (at a physiological level) and low toxicity. The fluorescence of the detecting system was steady for a wide pH range (5–8) and a long period of time (over 12 h). The most attractive point, its rapid cell-permeating ability, made it suitable for bioimaging with a 2 min incubation time and shortened the whole detecting period (cell-permeation and reaction), and thus could decrease background interference. It offered a convenient approach for determining exogenous or endogenous sulfite levels in living cells and further applications.

Graphical abstract: A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells

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Publication details

The article was received on 05 Aug 2018, accepted on 29 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01908H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells

    J. Xu, D. Zheng, M. Su, Y. Chen, Q. Jiao, Y. Yang and H. Zhu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01908H

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