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Ruthenium-catalyzed tandem annulation/arylation for the synthesis of unsymmetrical bis(heteroaryl)methanes

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Abstract

A new Ru-catalyzed tandem furan annulation/arylation strategy has been developed to afford unsymmetrical bis(heteroaryl)methanes by a reaction between propargyl amines and indoles. A series of bis(heteroaryl)methanes containing furan and indole as well as indole and imidazopyridine moieties have been synthesized in high yields. The reaction possibly proceeds through furan annulation followed by nucleophilic addition of indole.

Graphical abstract: Ruthenium-catalyzed tandem annulation/arylation for the synthesis of unsymmetrical bis(heteroaryl)methanes

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Publication details

The article was received on 03 Aug 2018, accepted on 07 Sep 2018 and first published on 07 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01892H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Ruthenium-catalyzed tandem annulation/arylation for the synthesis of unsymmetrical bis(heteroaryl)methanes

    S. Samanta and A. Hajra, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01892H

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