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An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

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Abstract

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Graphical abstract: An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

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Publication details

The article was received on 01 Aug 2018, accepted on 31 Aug 2018 and first published on 03 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01861H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

    P. Chen, Q. Zhang, J. Guo, L. Chen, Y. Wang and X. Zhang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01861H

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