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Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

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Abstract

A novel and efficient metal free, redox-neutral method for the synthesis of secondary thiocarbamates by cross-coupling of readily available thiophenol and isocyanides has been developed. The present methodology exhibits a broad substrate scope with good to excellent yields without an additive/extra oxidant under mild reaction conditions catalyzed by inexpensive iodine as the catalyst.

Graphical abstract: Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

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Publication details

The article was received on 31 Jul 2018, accepted on 04 Sep 2018 and first published on 04 Sep 2018


Article type: Communication
DOI: 10.1039/C8OB01855C
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Iodine-catalyzed cross-coupling of isocyanides and thiols for the synthesis of S-thiocarbamates

    R. S. Pathare, V. Patil, H. Kaur, A. K. Maurya, V. K. Agnihotri, S. Khan, N. Devunuri, A. Sharon and D. M. Sawant, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01855C

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