Jump to main content
Jump to site search


Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications

Author affiliations

Abstract

A systematic study on the iodine-mediated phosphoramidation reaction of amines and trialkyl phosphites was conducted, which not only disclosed the factors affecting the reaction but also revealed that it could proceed smoothly in CH2Cl2 at room temperature in open air. Using this method, various phosphoramidates with different aliphatic amines and aromatic amines were synthesized in good to excellent yields. Our present investigation shows that this underused method is actually a mild, practical and general way to synthesize phosphoramidates and will have wide applications.

Graphical abstract: Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Jul 2018, accepted on 31 Aug 2018 and first published on 01 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01840E
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    Reinvestigation of the iodine-mediated phosphoramidation reaction of amines and P(OR)3 and its synthetic applications

    X. Chen, Z. Xiao, H. Chu, B. Wang and A. Peng, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01840E

Search articles by author

Spotlight

Advertisements