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Issue 35, 2018
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Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor

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Abstract

Herein we report the reduction of aromatic nitriles into aldehydes with calcium hypophosphite in the presence of base and nickel(II) complex in a water/ethanol mixture. This catalytic system reduced efficiently a series of aromatic nitriles bearing different functional groups such as –Cl, –CF3, –Br, –CH3, –OCH3, –COOCH2CH3, –OH and –CHO. The corresponding aldehydes were isolated in moderate to excellent yields (30–94%).

Graphical abstract: Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor

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Publication details

The article was received on 21 Jul 2018, accepted on 22 Aug 2018 and first published on 22 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01751D
Citation: Org. Biomol. Chem., 2018,16, 6600-6605
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    Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor

    R. Mouselmani, A. Hachem, A. Alaaeddine, E. Métay and M. Lemaire, Org. Biomol. Chem., 2018, 16, 6600
    DOI: 10.1039/C8OB01751D

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