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Temperature-controlled sequential Suzuki–Miyaura reactions for preparing unsymmetrical terphenyls

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Abstract

A one-pot protocol of double Suzuki–Miyaura reactions has been developed for the synthesis of unsymmetrical terphenyls. In the absence of a ligand, potassium bromophenyltrifluoroborate reacts with arylboronic acid and then sequentially with a hetero/aryl bromide by controlling the reaction temperature, providing unsymmetrical p- and m-terphenyl compounds in moderate to good overall yields. This protocol provides a convenient and practical approach to unsymmetrical terphenyls under ligand-free and aerobic conditions.

Graphical abstract: Temperature-controlled sequential Suzuki–Miyaura reactions for preparing unsymmetrical terphenyls

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Publication details

The article was received on 13 Jul 2018, accepted on 28 Aug 2018 and first published on 30 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01661E
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Temperature-controlled sequential Suzuki–Miyaura reactions for preparing unsymmetrical terphenyls

    X. Li, C. Liu, L. Wang, Q. Ye, X. Jin and Z. Jin, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01661E

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