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Issue 35, 2018
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Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

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Abstract

A novel photocatalytic protocol is herein described for the preparation of functionalized phenols via radical alkylation of para-quinone methides under transition-metal-free conditions. The reaction is external oxidant free and performed at ambient temperature upon visible light irradiation, allowing the access to various desired products in satisfactory yields. The readily available 4-alkyl-1,4-dihydropyridines serve as the effective alkyl radical precursors.

Graphical abstract: Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

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Publication details

The article was received on 12 Jul 2018, accepted on 18 Aug 2018 and first published on 20 Aug 2018


Article type: Communication
DOI: 10.1039/C8OB01641K
Citation: Org. Biomol. Chem., 2018,16, 6391-6394
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    Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis

    Q. Wu, Q. Min, G. Ao and F. Liu, Org. Biomol. Chem., 2018, 16, 6391
    DOI: 10.1039/C8OB01641K

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