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Issue 35, 2018
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Synthesis and characterization of various 5′-dye-labeled ribonucleosides

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Abstract

Hitherto unknown chromophoric nucleosides are reported. This novel set of visibly coloured dye-labeled 5′-nucleosides, including 1,2,4,5-tetrazine, dicyanomethylene-4H-pyran, benzophenoxazinone, 9,10-anthraquinone and azobenzene chromophores, were prepared mainly under Cu-catalyzed azide–alkyne cycloaddition (CuAAC). The design criteria are outlined. Several derivatives possess in supplement a fluorescence property. The absorption and fluorescence spectra of all coloured nucleosides were recorded to study their potential as visible-range probes. Such nucleodyes are of great interest for future competitive lateral flow test MIP-based strips.

Graphical abstract: Synthesis and characterization of various 5′-dye-labeled ribonucleosides

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Publication details

The article was received on 07 Jul 2018, accepted on 21 Aug 2018 and first published on 21 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01606B
Citation: Org. Biomol. Chem., 2018,16, 6552-6563
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    Synthesis and characterization of various 5′-dye-labeled ribonucleosides

    C. De Schutter, V. Roy, P. Favetta, C. Pavageau, S. Maisonneuve, N. Bogliotti, J. Xie and L. A. Agrofoglio, Org. Biomol. Chem., 2018, 16, 6552
    DOI: 10.1039/C8OB01606B

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