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Issue 35, 2018
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Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

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Abstract

The bifunctional nature of the cinchonidine squaramides has been successfully employed to catalyze the enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones with 2-enoylpyridines under mild reaction conditions. Through this methodology, a broad range of optically active heterocyclic derivatives bearing both pyrazole and pyridine motifs have been synthesized in yields up to 88% and enantiomeric excess up to 96%.

Graphical abstract: Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

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Publication details

The article was received on 06 Jul 2018, accepted on 17 Aug 2018 and first published on 17 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01588K
Citation: Org. Biomol. Chem., 2018,16, 6470-6478
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    Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

    V. Sharma, A. Kaur, S. C. Sahoo and S. S. Chimni, Org. Biomol. Chem., 2018, 16, 6470
    DOI: 10.1039/C8OB01588K

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