Jump to main content
Jump to site search

Issue 31, 2018
Previous Article Next Article

Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups

Author affiliations

Abstract

A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.

Graphical abstract: Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Jul 2018, accepted on 24 Jul 2018 and first published on 24 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01584H
Citation: Org. Biomol. Chem., 2018,16, 5580-5584
  •   Request permissions

    Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups

    L. Hu and Y. Zhao, Org. Biomol. Chem., 2018, 16, 5580
    DOI: 10.1039/C8OB01584H

Search articles by author

Spotlight

Advertisements