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Dioxane-involving reaction for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines catalyzed by AgOTf

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Abstract

Dioxane was found to be involved in the reaction of 2-(arylethynyl)benzaldehydes and 3-aminopyrazine-2-carbohydrazide, and underwent a ring-opening reaction catalyzed by AgOTf. This domino type procedure provided an efficient method for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines in good yields via the loss of a molecule of 3-aminopyrazine-2-carboxamide.

Graphical abstract: Dioxane-involving reaction for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines catalyzed by AgOTf

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Publication details

The article was received on 04 Jul 2018, accepted on 27 Jul 2018 and first published on 28 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01572D
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Dioxane-involving reaction for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines catalyzed by AgOTf

    W. Pan, J. Liu and X. Wang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01572D

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