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Issue 30, 2018
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Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

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Abstract

Presented herein is an unprecedented transition-metal-free cyclization of methyl isocyanoacetate with aurone analogues catalyzed by NaOH. Various 2,3,4-trisubstituted pyrroles were obtained in excellent yields (up to 99%). The high efficiency of this synthetic procedure, coupled with the operational simplicity and atom economy, makes it an attractive method for the synthesis of polysubstituted pyrroles.

Graphical abstract: Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

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Publication details

The article was received on 03 Jul 2018, accepted on 18 Jul 2018 and first published on 18 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01558A
Citation: Org. Biomol. Chem., 2018,16, 5422-5426
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    Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues

    Z. Wang, Y. He and P. Shao, Org. Biomol. Chem., 2018, 16, 5422
    DOI: 10.1039/C8OB01558A

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