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Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

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Abstract

A novel metal-free multicomponent cascade reaction was developed for the construction of thiazine imides. This four-component cascade reaction had advantages of mild reaction conditions, wide substrate scope and good atom economy. Four new bonds were formed in one pot via a 6-exo-dig iodothiolation cyclization of homopropargylic amines. The corresponding E-configurational thiazine imide products possess an exocyclic vinyliodide functional group.

Graphical abstract: Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

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Publication details

The article was received on 03 Jul 2018, accepted on 31 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01557K
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Metal-free multicomponent cascade reactions of homopropargylic amines and acyl chlorides as well as potassium thiocyanate and diiodine: an access to thiazine imides

    J. Wu, Y. Kong, L. Liu, W. Chang and J. Li, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01557K

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