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Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen

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Abstract

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.

Graphical abstract: Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen

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Publication details

The article was received on 29 Jun 2018, accepted on 31 Jul 2018 and first published on 02 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01532E
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen

    X. Li, T. Wang, Y. Lu, S. Ji, Y. Huo and B. Liu, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01532E

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