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Issue 35, 2018
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Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

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Abstract

A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.

Graphical abstract: Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

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Publication details

The article was received on 23 Jun 2018, accepted on 14 Aug 2018 and first published on 14 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01486H
Citation: Org. Biomol. Chem., 2018,16, 6430-6437
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    Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo[1,2-a]pyridines

    P. R. Nitha, M. M. Joseph, G. Gopalan, K. K. Maiti, K. V. Radhakrishnan and P. Das, Org. Biomol. Chem., 2018, 16, 6430
    DOI: 10.1039/C8OB01486H

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