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Issue 28, 2018
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Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

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Abstract

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition. Their features are high labeling yields, rapid and efficient bioconjugation, metabolically stable luciferin-based end products, and applicability to orthogonal two-step labeling of sensitive biomolecules.

Graphical abstract: Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

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Publication details

The article was received on 19 Jun 2018, accepted on 02 Jul 2018 and first published on 02 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01434E
Citation: Org. Biomol. Chem., 2018,16, 5102-5106
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    Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

    F. Gao, C. Ieritano, K.-T. Chen, G. M. Dias, J. Rousseau, F. Bénard and Y. Seimbille, Org. Biomol. Chem., 2018, 16, 5102
    DOI: 10.1039/C8OB01434E

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