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Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

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Abstract

A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.

Graphical abstract: Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

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Publication details

The article was received on 17 Jun 2018, accepted on 04 Sep 2018 and first published on 05 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01429A
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

    Q. Yang, M. Lou, Z. Yin, Z. Deng, Q. Ding and Y. Peng, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01429A

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