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Recent developments in functionalization of acyclic α-keto amides

Abstract

α-Keto amide is a key frame in biology, medicinal chemistry and synthetic chemistry as drug molecules and key intermediates. Based on the structural aspect, acyclic α-keto amide has multiple reactive centres which have electrophilic as well as nucleophilic characters. In this review, we focus on the recent developments of both asymmetric and achiral reactions involving acyclic α-keto amide as the reactant for the synthesis of cyclic and acyclic molecules through the formation of C-C, C-O, C-N and C-H bonds. Based on the reactivity of α-keto amide, this article is divided into three major classes such as 1. mono functionalization, 2. dual functionalization, and 3. triple functionalization of α-keto amide which are further divided into sub-classes as well. Over 50 examples including our own work have been demonstrated for the functionalization of acyclic α-keto amide since 1992. Moreover, the usefulness of α-keto amide has been shown for the synthesis of biologically active molecules, synthetic intermediates, heterocycles, valuable compounds, building blocks and metal complexes.

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Publication details

The article was received on 15 Jun 2018, accepted on 06 Aug 2018 and first published on 06 Aug 2018


Article type: Review Article
DOI: 10.1039/C8OB01423J
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Recent developments in functionalization of acyclic α-keto amides

    A. Muthukumar, S. Subramani and G. Sekar, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB01423J

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