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Issue 31, 2018
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Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

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Abstract

A simple and efficient approach has been developed for the synthesis of imidazo[1,5-a]pyridines using the elemental sulfur mediated sequential dual oxidative Csp3–H amination of 2-pyridyl acetates and amines under metal- and peroxide-free conditions. Broad substrate scope, operational simplicity and gram-scale ability make this chemistry very practical.

Graphical abstract: Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

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Publication details

The article was received on 12 Jun 2018, accepted on 16 Jul 2018 and first published on 23 Jul 2018


Article type: Communication
DOI: 10.1039/C8OB01391H
Citation: Org. Biomol. Chem., 2018,16, 5570-5574
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    Metal-free synthesis of imidazo[1,5-a]pyridines via elemental sulfur mediated sequential dual oxidative Csp3–H amination

    J. Sheng, J. Liu, H. Zhao, L. Zheng and X. Wei, Org. Biomol. Chem., 2018, 16, 5570
    DOI: 10.1039/C8OB01391H

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