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Issue 35, 2018
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Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams

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Abstract

Enabled by nickel catalysis, a practical access to the synthesis of 4-benzyl-3,3-difluoro-γ-lactams has been developed via radical tandem cyclisation/arylation. This method features a nickel catalyst, high reaction efficiency, and good substrate tolerance and scope. This protocol proceeds through an intramolecular radical addition to form a primary alkyl radical followed by intermolecular Suzuki-type coupling.

Graphical abstract: Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams

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Publication details

The article was received on 12 Jun 2018, accepted on 20 Aug 2018 and first published on 21 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01389F
Citation: Org. Biomol. Chem., 2018,16, 6491-6498
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    Nickel-catalysed radical tandem cyclisation/arylation: practical synthesis of 4-benzyl-3,3-difluoro-γ-lactams

    W. Mai, F. Wang, X. Zhang, S. Wang, Q. Duan and K. Lu, Org. Biomol. Chem., 2018, 16, 6491
    DOI: 10.1039/C8OB01389F

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