Issue 29, 2018

TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Abstract

Highly selective and catalyst-free tandem multi-functionalization of terminal alkynes was developed with 2-oxindoles and benzo-furan-2(3H)-one using TEMPO both as a radical promoter and a trapping reagent. This work expands the scope of the radical-cascade addition/trapping process of alkynes for the effective construction of various β-oxyl carbonyls in moderate to good yields.

Graphical abstract: TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Supplementary files

Article information

Article type
Communication
Submitted
11 Jun 2018
Accepted
30 Jun 2018
First published
02 Jul 2018

Org. Biomol. Chem., 2018,16, 5228-5231

TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one

Q. Liu, J. Liu, L. Cheng, D. Wang and L. Liu, Org. Biomol. Chem., 2018, 16, 5228 DOI: 10.1039/C8OB01380B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements