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Cyclotrimerization of phenylacetylene catalyzed by a cobalt half-sandwich complex embedded in an engineered variant of transmembrane protein FhuA

Abstract

An (5-cyclopentadienyl)cobalt(I) complex was covalently incorporated in an engineered variant of the transmembrane protein Ferric hydroxamate uptake protein component: A, FhuA ΔCVFtev, using the thiol-ene reaction. CD spectrum shows the structural integrity of the biohybrid catalyst. MALDI-TOF of the segment containing the anchoring site for the cobalt complex Cys545 confirmed sucessful conjugation. This biohybrid catalyst catalyzed the [2+2+2] cycloaddition of phenylacetylene to give a mixture of regiosomeric 1,2,4- and 1,3,5-triphenylbenzene in aqueous medium.

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Publication details

The article was received on 10 Jun 2018, accepted on 05 Jul 2018 and first published on 05 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01369A
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Cyclotrimerization of phenylacetylene catalyzed by a cobalt half-sandwich complex embedded in an engineered variant of transmembrane protein FhuA

    J. Okuda, U. Schwaneberg, A. Thiel, D. F. Sauer, S. Mertens, T. Polen and H. Chen, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB01369A

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