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Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

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Abstract

A simple and facile catalyst-free method for the construction of α-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various α-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1,4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.

Graphical abstract: Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

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Publication details

The article was received on 08 Jun 2018, accepted on 30 Aug 2018 and first published on 13 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01349G
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

    W. Wei, L. Wang, H. Yue, Y. Jiang and D. Yang, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01349G

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