Jump to main content
Jump to site search


o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties

Author affiliations

Abstract

o-Nitrobenzyl (o-NB) derivatives are the most widely applied photoremovable groups for the study of dynamic biological processes. By introducing different substituents to the benzylic position we were able to generate a fluorescence signal upon irradiation. This signal originates from the formation of a nitrosoketone by-product able to achieve a keto–enol tautomerism leading to pi-conjugated α-hydroxystilbene derivatives. These o-NB caging groups can be used to directly monitor the uncaging event by the release of a detectable fluorescent side-product.

Graphical abstract: o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jun 2018, accepted on 02 Aug 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01330F
Citation: Org. Biomol. Chem., 2018, Advance Article
  •   Request permissions

    o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties

    E. Abou Nakad, F. Bolze and A. Specht, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01330F

Search articles by author

Spotlight

Advertisements