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Issue 27, 2018
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Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A

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Abstract

Asymmetric total synthesis of naturally occurring γ-butenolide containing [4.4]spiro-tetrahydrofuran lanceolactone A has been reported in the present work. Bimetallic (“Pd–Cu”) cascade cyclization was the crucial reaction employed for the construction of the γ-butenolide framework of the natural product. Subsequently, iodocyclization and reductive deiodination through a transfer hydrogenation reaction were applied to access the target molecule in an efficient manner.

Graphical abstract: Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A

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Publication details

The article was received on 06 Jun 2018, accepted on 22 Jun 2018 and first published on 22 Jun 2018


Article type: Paper
DOI: 10.1039/C8OB01328D
Citation: Org. Biomol. Chem., 2018,16, 5027-5035
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    Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A

    R. K. Acharyya and S. Nanda, Org. Biomol. Chem., 2018, 16, 5027
    DOI: 10.1039/C8OB01328D

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