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Issue 27, 2018
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Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

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Abstract

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.

Graphical abstract: Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

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Publication details

The article was received on 06 Jun 2018, accepted on 19 Jun 2018 and first published on 19 Jun 2018


Article type: Communication
DOI: 10.1039/C8OB01326H
Citation: Org. Biomol. Chem., 2018,16, 4973-4976
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    Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

    H. Lin, H. Lyu, S. Zhou, J. Yu, N. P. Keller, L. Chen and W. Yin, Org. Biomol. Chem., 2018, 16, 4973
    DOI: 10.1039/C8OB01326H

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