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Issue 31, 2018
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Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy

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Abstract

A new protocol for the direct synthesis of quinolines from enones and 2-aminobenzyl alcohols via iridium-catalyzed transfer hydrogenative reactions has been demonstrated. This method employs easily available [IrCp*Cl2]2/t-BuOK as the efficient catalyst system, proceeding with the merits of high step- and atom efficiency, mild reaction conditions and operational simplicity. The experimental studies suggest that the reactions start with transfer hydrogenation, followed by the Friedländer reaction to give the final products.

Graphical abstract: Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy

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Publication details

The article was received on 05 Jun 2018, accepted on 20 Jul 2018 and first published on 20 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01321G
Citation: Org. Biomol. Chem., 2018,16, 5707-5711
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    Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy

    B. Xiong, Y. Wang, Y. Liu, Y. Bao, Z. Liu, Y. Zhang and Y. Ling, Org. Biomol. Chem., 2018, 16, 5707
    DOI: 10.1039/C8OB01321G

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