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Enantioselective total synthesis and biological evaluation of (−)-solanacol

Abstract

An enantioselective synthesis of the phenyl ring-containing strioglactone, (-)-solanocol, is described. Application of a Dynamic Kinetic Resolution (DKR) in the stereo-defining step enabled a step-economical synthesis to be achieved, and allowed access to natural and non-natural enantiomers with equal facility. Results of seed germination assays and Differential Scanning Fluorimetry measurements with the known strigolactone receptor protein, DAD2, are reported.

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Publication details

The article was received on 31 May 2018, accepted on 11 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01287C
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
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    Enantioselective total synthesis and biological evaluation of (−)-solanacol

    C. McErlean, L. J. Bromhead, A. R. Norman, B. J. Janssen and K. C. Snowden, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB01287C

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