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Palladium-catalyzed oxidative C–H/C–H cross-coupling of imidazopyridines with azoles

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Abstract

An effective palladium-catalyzed oxidative C–H/C–H cross-coupling of imidazopyridines with azoles using air as the oxidant has been developed. This protocol provides a straightforward and operationally simple method for the synthesis of 3-azolyl-imidazopyridines in moderate to good yields and with good functional group tolerance. The biological evaluation revealed that the newly synthesized compounds 3e and 3h exhibit significant in vitro antiproliferative activities against human-derived lung cancer cell lines compared with the positive control, 5-fluorouracil.

Graphical abstract: Palladium-catalyzed oxidative C–H/C–H cross-coupling of imidazopyridines with azoles

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Publication details

The article was received on 29 May 2018, accepted on 02 Aug 2018 and first published on 03 Aug 2018


Article type: Paper
DOI: 10.1039/C8OB01263F
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Palladium-catalyzed oxidative C–H/C–H cross-coupling of imidazopyridines with azoles

    T. Guo, J. Liang, S. Yang, H. Chen, Y. Fu, S. Han and Y. Zhao, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB01263F

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