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Issue 32, 2018
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A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones

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Abstract

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls including 1,3-diketones and ethyl acetoacetate has been developed for the facile synthesis of quinazolinones. In the presence of AgNO3/K2S2O8, the diketones could be converted to radicals and coupled with N-cyanamide alkenes to undergo a cyclization cascade for accessing quinazolinones. This method features mild reaction conditions, readily available starting materials, and valuable synthetic utility. Moreover, the products could be further transformed into various heterocycles.

Graphical abstract: A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones

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Publication details

The article was received on 28 May 2018, accepted on 24 Jul 2018 and first published on 25 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01252K
Citation: Org. Biomol. Chem., 2018,16, 5899-5906
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    A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones

    G. Xu, C. Tong, S. Cui and L. Dai, Org. Biomol. Chem., 2018, 16, 5899
    DOI: 10.1039/C8OB01252K

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