Jump to main content
Jump to site search


Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives

Abstract

Enantioselective synthesis of α-perfluoroalkylated cyclic amino acids and their derivatives was elaborated using organocatalytic Strecker reaction with 5-7 membered cyclic ketimines. Prepered amino nitriles could be transformed into chiral Rf-prolines and their 6,7-membered homologues as well as the corresponding amides and diamines (yields up to 99%, up to >99% ee).

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 May 2018, accepted on 07 Sep 2018 and first published on 11 Sep 2018


Article type: Paper
DOI: 10.1039/C8OB01223G
Citation: Org. Biomol. Chem., 2018, Accepted Manuscript
  •   Request permissions

    Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives

    N. Voznesenskaia, O. Shmatova, V. N. Khrustalev and V. Nenajdenko, Org. Biomol. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8OB01223G

Search articles by author

Spotlight

Advertisements