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Issue 31, 2018
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CoCl2-promoted TEMPO oxidative homocoupling of indoles: access to tryptanthrin derivatives

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Abstract

A novel TEMPO/CoCl2-promoted aerobic oxidation of indoles was developed. The reaction provided one-step access to tryptanthrin derivatives in moderate to good yields and excellent regioselectivity via a cascade process. The reactions could be carried out under mild reaction conditions with varying functional group tolerance, especially halogen functional groups. Mechanistic studies disclosed that the oxygen atom in the desired product originated from molecular dioxygen.

Graphical abstract: CoCl2-promoted TEMPO oxidative homocoupling of indoles: access to tryptanthrin derivatives

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Publication details

The article was received on 23 May 2018, accepted on 23 Jul 2018 and first published on 24 Jul 2018


Article type: Paper
DOI: 10.1039/C8OB01216D
Citation: Org. Biomol. Chem., 2018,16, 5699-5706
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    CoCl2-promoted TEMPO oxidative homocoupling of indoles: access to tryptanthrin derivatives

    H. Liao, X. Peng, D. Hu, X. Xu, P. Huang, Q. Liu and L. Liu, Org. Biomol. Chem., 2018, 16, 5699
    DOI: 10.1039/C8OB01216D

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